Product Information
NADPH(sodium salt)
Formal Name: β-Nicotinamide adenine dinucleotide 2′-phosphate reduced tetrasodium salt
Synonym: Dihydronicotinamide adenine dinucleotide phosphate;Nicotinamide adenine dinucleotide phosphate (NADPH)
MF:C21H26N7O17P3·4Na
FW: 833.4
Purity:≥95% (HPLC assay)
Contents: ≥90%
Product Description:
This product is white to yellow lyophilized powder in appearance.The maximum absorption wave lengths are 260nm and 340nm.
NADPH is the reduced form of NADP+. In animal, NADPH is a product of the pentose phosphate pathway. The isocitrate dehydrogenase mechanism appears to be the major source of NADPH in fat tissue and possibly also liver cells.1 In plant,NADPH is produced by ferredoxin-NADP+ reductase in the last step of the electron chain of the light reactions of photosynthesis.
NADPH provides the reducing equivalents for biosynthetic reactions and the oxidation-reduction involved in protecting against the toxicity of reactive oxygen species (ROS), allowing the regeneration of glutathione (GSH).2 NADPH is also used for anabolic pathways, such as lipid synthesis, cholesterol synthesis, and fatty acid chain elongation.3 Recent studies suggest that NADPH plays critical roles in neuronal survival and cardiovascular protection.4
Preparation instructions /storage/stability:
It is recommended to store NADPH desiccated at –20 °C, protected from light. It should be stable for at least one yearat –20 °C.
The solubility of NADPH in water is approximately 500mg/ml.
After being dissolute, we do not recommend to store the solution for more than one day.
Precautions and disclaimer:
This product is for R&D for life science, healthcare industry, fine chemistry industry, cosmetic industry, not for household or other uses.
When using this product, do not get it in eyes, or on skin. We recommend user wash thoroughly after handling if contamination of skin occurred.
Please consult the Material Safety Data Sheet for information regarding hazards and safe handling practices before use.
References:
1. Palmer, Michael. Supply of NADPH for fatty acid synthesis. Metabolism Course Notes. Retrieved 6 April 2012.
2.Rush GF, Gorski JR, Ripple MG, Sowinski J, Bugelski P, Hewitt WR. "Organic hydroperoxide-induced lipid peroxidation and cell death in isolated hepatocytes". Toxicology and Applied Pharmacology. (May 1985)
3. Nauseef W.M. Biological roles for the NOX family NADPH oxidases. J. Biol. Chem. (2008).
4. Li M, Zhou ZP, Sun M， Cao L, Chen J, Qin YY, Gu JH, Han F, Sheng R, Wu JC, Ding Y, Qin ZH. NADPH, a pentose phosphate pathway product, might be a novel drug candidate for ischemic stroke. Stroke, 2016 Jan 47(1):187-95.
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